2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W270557S
    Lodoxamide impurity 2-d10
    Lodoxamide impurity 2-d10 is deuterium labeled 2-(Diethylamino)-2-oxoacetic acid.
    Lodoxamide impurity 2-d<sub>10</sub>
  • HY-135245
    Ezetimibe hydroxy glucuronide
    Ezetimibe hydroxy glucuronide (SCH 488128) is a trace metabolite detected in dog and human plasma samples after oral administration of Ezetimibe (HY-17376).
    Ezetimibe hydroxy glucuronide
  • HY-144773
    Loxoprofenol-SRS
    Loxoprofenol-SRS, an active metabolite of Loxoprofen, is a new intravenous NSAID. Loxoprofenol-SRS exhibits significantly stronger anti-inflammatory and analgesic activities.
    Loxoprofenol-SRS
  • HY-101433
    N-Acetylprocainamide hydrochloride
    N-Acetylprocainamide (Acecainide) hydrochloride is a class III antiarrhythmic, which blocks K+ channels.
    N-Acetylprocainamide hydrochloride
  • HY-147333
    Trimipramine N-oxide
    Trimipramine N-oxide is an active metabolite of the tricyclic antidepressant trimipramine. Trimipramine N-oxide inhibits the human monoamine transporters for noradrenaline (hNAT), serotonin (hSERT), dopamine (hDAT) and the human organic cation transporters (hOCT1 and hOCT2) with IC50s of 11.7, 3.59, 9.4, 9.35 and 27.4 nM, respectively. Trimipramine N-oxide can be used for the research of depression and anxiety.
    Trimipramine N-oxide
  • HY-136142
    Prasugrel chloride impurity
    Prasugrel chloride impurity is a catp impurity of Prasugrel, exacted from patent US20130345428A1, line 0053. Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation.
    Prasugrel chloride impurity
  • HY-144146S
    Pramipexole impurity 7-d10
    Pramipexole impurity 7-d10 is the deuterium labeled Pramipexole impurity 7[1].
    Pramipexole impurity 7-d<sub>10</sub>
  • HY-W019726S1
    Dehydro Nifedipine-13C,d3
    Dehydro Nifedipine-13C,d3 is a deuterated labeled Dehydro Nifedipine. Dehydro nifedipine (BAY-b 4759) is a metabolite of Nifedipine (HY-B0284). Nifedipine (BAY-a-1040) is a potent calcium channel blocker and an agent of choice for cardiac insufficiencies.
    Dehydro Nifedipine-<sup>13</sup>C,d<sub>3</sub>
  • HY-W001080S1
    3,4-Dihydroxybenzeneacetic acid-d3
    3,4-Dihydroxybenzeneacetic acid-d3 is deuterium-labeled 3,4-Dihydroxybenzeneacetic acid (HY-W001080).
    3,4-Dihydroxybenzeneacetic acid-d<sub>3</sub>
  • HY-161481
    Melamine/bov igG
    Melamine/bov igG is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Melamine/bov igG
  • HY-143968S
    Ketotifen impurity 3-d4
    Ketotifen impurity 3-d4 is the deuterium labeled Ketotifen impurity 3[1].
    Ketotifen impurity 3-d<sub>4</sub>
  • HY-12771S1
    O-desmethyl Mebeverine acid-d5 hydrochloride
    O-desmethyl Mebeverine acid-d5 (hydrochloride) is the deuterium labeled O-desmethyl Mebeverine acid.
    O-desmethyl Mebeverine acid-d<sub>5</sub> hydrochloride
  • HY-12770S
    Mebeverine alcohol-d5
    		≥98.0%
    Mebeverine alcohol-d5 is the deuterium labeled Mebeverine alcohol, which is a metabolite of Mebeverine.
    Mebeverine alcohol-d<sub>5</sub>
  • HY-148642
    12-Hydroxynevirapine
    12-Hydroxynevirapine (12-hydroxy-NVP; 12-OH-NVP) is a major oxidative metabolite of Nevirapine (HY-10570). Nevirapine is a non-nucleoside reverse transcriptase inhibitor indicated for the HIV-1 infections. Nevirapine causes idiosyncratic hepatotoxicity and mild-to-severe skin rashes. 12-Hydroxynevirapine, a non-reactive metabolite, can be bioactivated by sulphotransferases (SULTs) in the liver and skin, yielding the reactive species 12-Sulphoxy-nevirapine.
    12-Hydroxynevirapine
  • HY-G0021S1
    N-Desmethylclozapine-d8 hydrochloride
    		99.74%
    N-Desmethylclozapine-d8 (hydrochloride) is the deuterium labeled N-Desmethylclozapine hydrochloride. N-Desmethylclozapine hydrochloride is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine hydrochloride is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine hydrochloride is also a δ-opioid agonist[1][2][3].
    N-Desmethylclozapine-d<sub>8</sub> hydrochloride
  • HY-W424779
    5-Carboxy-2′-deoxyuridine
    5-Carboxy-2′-deoxyuridine is a metabolite of Trifluridine. 5-Carboxy-2′-deoxyuridine is a methyl oxidation product of Thymidine that can be formed by menadione-mediated photosensitization of Thymidine.
    5-Carboxy-2′-deoxyuridine
  • HY-135111
    4-Desmethoxy Omeprazole
    4-Desmethoxy Omeprazole is the active metabolite of Omeprazole. Omeprazole, a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria.
    4-Desmethoxy Omeprazole
  • HY-126857
    5-Hydroxyomeprazole
    5-Hydroxyomeprazole is the major metabolite of Omeprazole (HY-B0113).
    5-Hydroxyomeprazole
  • HY-144141S
    Nortriptyline impurity 3-d3 hydrochloride
    Nortriptyline impurity 3-d3 (hydrochloride) is the deuterium labeled Nortriptyline impurity 3 hydrochloride[1].
    Nortriptyline impurity 3-d<sub>3</sub> hydrochloride
  • HY-N3995S
    5β-Dihydrocortisol-d6
    5β-Dihydrocortisol-d6 is the deuterium labeled 5β-Dihydrocortisol. 5β-Dihydrocortisol, a metabolite of Cortisol, is a potential mineralocorticoid. 5β-Dihydrocortisol can potentiate glucocorticoid activity in raising the intraocular pressure. 5β-Dihydrocortisol causes breast cancer cell apoptosis[1][2][3][4][5].
    5β-Dihydrocortisol-d<sub>6</sub>
Cat. No. Product Name / Synonyms Application Reactivity